We report a case of primary cutaneous infection by the emerging fungus Aspergillus ustus in an immunosuppressed patient after a domestic accident. Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. We report the first outbreak of invasive infection caused by A . Med Mycol. Jun;45(4) Clustering of invasive Aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an.

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Lippincott Williams and Wilkins; The results of molecular analyses suggest genetic similarity of isolates recovered from patients. Also, several patients who were not found to have A. Recognition of invasive infections that occurred in 2 clusters of hematopoietic stem cell transplant HSCT recipients in our institution prompted us to perform a more thorough clinical investigation and environmental sampling to identify potential sources of acquisition.

We report the first outbreak of invasive infection caused by A. Most of these infections were caused by A. A spot map depicting case-patient location and timeline relating location to time of diagnosis was created.

Nakai K, Kanda Y, Mineishi S Primary cutaneous aspergillosis caused by Aspergillus ustus following reduced-intensity stem cell transplantation. Journal of Clinical Microbiology. Filtenborg O 1 Introduction to food-borne fungi. More timely environmental sampling may apergillus captured more environmental A. Analyses of Isolates Eleven Aspergillux. Patients 2, 4, 5, and 6 were moved to a variety of rooms around the time of diagnosis as indicated by their location in multiple rooms. Sterigmatocystis usta Bainier Aspergillus minutus Abbott Aspergillus ustus var.

Aspergillus ustus infections among transplant recipients. Many reported cases have been either primary cutaneous disease or disseminated infection, however, we cannot draw firm conclusions regarding the types of infections this organism causes because of the high likelihood of reporting bias. This study also emphasizes the importance of establishing microbial diagnoses to the species level; asperglllus obtained is important for infection control and, possibly, to guide antifungal therapies.

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Guide to clinically significant fungi. Views Read Edit View history.

Although we do not know breakpoints of A. Estimating that patients were admitted for HSCT during the at-risk period, the highest overall attack rate was 1. Results Outbreak Asoergillus We identified 2 clusters of A. The pH of the medium is not modified by the species final pH 6. Of note, the lung transplant patient appeared to be colonized with a strain of A.

At the time of his diagnosis and death, patient 2 resided in aspergilpus room directly adjacent to and above the room of patient 5, albeit 2 years earlier Figure 1.

Aspergillus ustus | Aspergillus & Aspergillosis Website

Acknowledgments We thank Estella Whimbey and Nancy Whittington for their help with acquiring information on hospital airflow and construction activity, Robin Olsen for performing the environmental aspergillua sampling, Chris Davis for database support, David Madtes and Pat McDowell for obtaining bronchoscopic information, and S.

Like other members of the genus Aspergillusthe A.

The conidia heads are columnar when mature with hemispherical or globose and generally pigmented vesicles. Aspergillys ustus group colony on Modified Leonian’s agar. Bilateral pulmonary consolidation, skin lesion. The conidia are 3. From Wikipedia, the free encyclopedia.

Fukuda T, Boeckh M, Carter RA Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning.

The spectrum of disease reported due to A. Thus, the source of A. The most common clinical presentations of A. Molecular typing of A. Fever, chest pain, nodular pulmonary opacity. CMV, parainfluenza pneumonia; BK virus hemorrhagic cystitis. The Journal of Antibiotics. We identified 2 clusters of A. Members of this group are rare human pathogens; only 15 cases of systemic infection have been reported in the literature sinceand more than half of these occurred in the past 10 years Table A1 4 – Mixtures were subjected to 3 cycles of freeze-thaw in liquid nitrogen, alternating with vortexing with 0.

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In-vitro testing of susceptibility to amphotericin B is a reliable predictor of clinical outcome in invasive aspergillosis. Aspergillus ustus has been found on the surfaces of walls of caves and in indoor air of buildings [8] including hospitals, [3] [9] soils and bat dung. Six patients with infections were identified; 3 infections each occurred in both and Disseminated aspergillosis caused by Aspergillus ustus in a patient following allogeneic peripheral stem cell transplantation.

Charts were reviewed for clinical data demographics, underlying disease, transplantation characteristics, antifungal therapies, radiographic and laboratory studies, and outcome. It is moss-green on all studied materials.

Aspergillus ustus

Pulmonary infiltrates and erythematous papular skin lesions. Although the clinical isolates kstus different from the ATCC strain, the genetic similarity of case strains may represent a strain common to our local environment. This observation is important, given the possibility of common-source acquisition of a potentially antifungal drug—resistant organism. However, the true incidence of A.

Last modified: December 28, 2019